Reduced Tyk2 gene expression in b-cells due to natural mutation determines susceptibility to virus-induced diabetes
نویسندگان
چکیده
Reduced Tyk2 gene expression in b-cells due to natural mutation determines susceptibility to virus-induced diabetes Kenichi Izumi1,2,3,*, Keiichiro Mine1,*, Yoshitaka Inoue1, Miho Teshima1, Shuichiro Ogawa1, Yuji Kai1, Toshinobu Kurafuji1, Kanako Hirakawa1, Daiki Miyakawa1, Haruka Ikeda1, Akari Inada4, Manami Hara5, Hisakata Yamada6, Koichi Akashi2, Yoshiyuki Niho2, Keisuke Ina7, Takashi Kobayashi8, Yasunobu Yoshikai6, Keizo Anzai3, Teruo Yamashita9, Hiroko Minagawa9, Shuji Fujimoto1, Hironori Kurisaki1, Kazuya Shimoda10, Hitoshi Katsuta1 & Seiho Nagafuchi1
منابع مشابه
Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes
Accumulating evidence suggests that viruses play an important role in the development of diabetes. Although the diabetogenic encephalomyocarditis strain D virus induces diabetes in restricted lines of inbred mice, the susceptibility genes to virus-induced diabetes have not been identified. We report here that novel Tyrosine kinase 2 (Tyk2) gene mutations are present in virus-induced diabetes-se...
متن کاملTYK2 Promoter Variant and Diabetes Mellitus in the Japanese
BACKGROUND Recently, natural mutation of Tyrosine kinase 2 (Tyk2) gene has been shown to determine susceptibility to murine virus-induced diabetes. In addition, a previous human genome-wide study suggested the type 1 diabetes (T1D) susceptibility region to be 19p13, where the human TYK2 gene is located (19p13.2). METHODS Polymorphisms of TYK2 gene at the promoter region and exons were studied...
متن کاملEffect of Silymarin on Blood Glucose concentration and Pax4 Gene Expression and Histopathology of Pancreatic Tissue in Streptozotocin-Induced Diabetic Wistar Rats
Aim and Background: Considering the high rates of diabetes in Iran and the world and also due to the lower side effects of medicinal plants compared to industrial and chemical arbitrators, this study examined the effect of the active ingredient of tall moss (silymarin) on the expression of pax4 gene, one of the key genes for development and reconstruction of pancreatic beta cells. Material ...
متن کاملTYK2 is a key regulator of the surveillance of B lymphoid tumors.
Aberrant activation of the JAK-STAT pathway has been implicated in tumor formation; for example, constitutive activation of JAK2 kinase or the enforced expression of STAT5 induces leukemia in mice. We show here that the Janus kinase TYK2 serves an opposite function. Mice deficient in TYK2 developed Abelson-induced B lymphoid leukemia/lymphoma as well as TEL-JAK2-induced T lymphoid leukemia with...
متن کاملCloning and expression of fragment of the rabies virus nucleoprotein gene in Escherichia coli and evaluation of antigenicity of the expression product
Rabies virus nucleoprotein (N protein) encapsidates genomic RNA of the virus and forms the viral ribonucleoprotein complex. These N proteins represent highly organized structures which activate proliferation of B cells and production antibodies against the N protein. In addition to the B cell, the rabies virus N protein has been shown to induce potent T helper cell responses resulting in a long...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015